Endocrine Abstracts

Introduction: Bariatric surgery is currently considered the most effective treatment for morbid obesity. Laparoscopic gastric bypass (LGB) and laparoscopic sleeve gastrectomy (LSG) are the most widely used bariatric procedures today.Objectives: In this study we compared LGB and LSG in order to establish whether there is any superiority of one or the other in effectiveness and complications.Methods: We included all the patients who ...

Introduction: Bariatric surgery is currently considered the most effective treatment for morbid obesity, although rates of weight loss and comorbidities resolution differ among bariatric techniques and depending on preoperative factors.Objectives: In this study we analyse possible factors that influence the outcome of bariatric surgery (weight loss and improvement in metabolic comorbidities) in order to identify those patients most likely to benefit from...

: Prostate cancer (PCa) is the most common cancer among men in developed countries. Unfortunately, the heterogeneity of this malignancy hinders the finding of new biomarkers and therapeutic tools. A potential factor contributing to PCa is alternative splicing, which can generate the appearance of oncogenic variants involved in PCa aggressiveness. Thus, we hypothesized that the alteration of the splicing machinery (spliceosome components and splicing factors (SFs)) could be ass...

Prevalence of metabolic syndrome (MetS) and type-2 Diabetes (T2D) is growing dramatically worldwide. Loss of phenotypic flexibility, i.e. the difficulty to cope with different stressors to maintain metabolic homeostasis, contributes critically to the development of MetS/T2DM. Thus, it is essential to identify the key modifiers of phenotypic plasticity that define an individual’s susceptibility to develop T2DM. In this scenario, emerging evidence indicates that, under adve...

Obesity, a disease that is growing at epidemic proportions worldwide, is caused by a combination of genetic and lifestyle factors. One of the most common pathologies associated with obesity is hepatic steatosis, an accumulation of fat within the liver that can progress to liver fibrosis, cirrhosis, and ultimately lead to hepatocellular carcinoma. There is emerging evidence that alternative mRNA splicing, the key mechanism providing transcript and protein diversity, is dysregul...

Introduction: X-linked adrenoleukodystrophy (X-ALD) is a rare condition presented mainly in males during childhood and early adulthood. It represents almost 10% of primary adrenal insufficiency (PAI) or Addison’s disease cases.Clinical case: A 67-year-old male was diagnosed at the age of 61 with PAI during testing for mesenteric paniculitis while admitted in Internal Medicine service. He was treated with hydrocortisone and referred to outpatient end...

Introduction: Catecholamine-secreting tumours derived from the adrenal medulla and the nodes of the autonomic nervous system are known as pheochromocytomas or paragangliomas, respectively. Although their clinical manifestations are similar, their differentiation is important from an epidemiological and prognostic point of view and their possibility of being associated with genetic syndromes.Case report: We present a case of a 16 year old patient, with no...

Introduction: In patients with human immunodeficiency virus (HIV) infection, the prevalence of osteoporosis is higher in comparison with the general population. Anti-retroviral therapy (ART) use seems to be a possible risk factor there is also high prevalence of vitamin D deficiency among people living with HIV.Objectives: To describe bone mineral density (BMD) status in HIV-infected patients as well as its associated risk factors such as vit D levels.</...

Objectives: MODY diabetes is the most common form of monogenic diabetes, encompassing a heterogeneous group of disorders whose primary defect results from mutations in one of at least seven genes recognized, associated with a primary defect in insulin secretion. It has early onset and autosomal dominant inheritance.Our objective was to evaluate the results of monogenic diabetes clinic of the Endocrinology and Nutrition Department during 2008–2012.</...

Introduction: Cardiovascular disease is present in up to 60% of patients diagnosed of acromegaly and is responsible of the major related morbidity and mortality.Case report: A 79-year-old-woman with previous history of diabetes mellitus and hypertension was admitted for acute pulmonary edema. Transthoracic echocardiogram showed a severe left ventricular dysfunction with an ejection fraction of 20%, dilated left ventricle and left atrium with a moderate m...